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Signaling and Metabolism
Many human diseases, such as diabetes, neurodegeneration, cancer and heart problems, are linked to old age. The Wu Laboratory studies the interface between cellular metabolism and signal transduction, with a specific focus on key steps in glucose and lipid metabolism, in order to understand the ways that nutrients can delay aging effects and thus postpone the onset of disease.
Featured Publications
Lee H et al. Proteomic and metabolic characterization of a mammalian cellular transition from quiescence to proliferation. Cell Rep.
Waldhart AN et al. Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin. Cell Rep.
Wu N et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell.
The Wu Lab is looking for postdocs!
A postdoctoral fellow position is immediately open in the Wu Lab, which investigates glucose and lipid metabolism in order to understand how nutrients can delay the effects of aging and delay or prevent disease onset. There are several projects available, including genetic models, signaling mechanisms using tissue-cultured cells, protein purification, and structural analysis using cryo-EM. The position is supported by a recent R01. Learn more and apply here.