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Signaling and Metabolism
Many human diseases, such as diabetes, neurodegeneration, cancer and heart problems, are linked to old age. The Wu Laboratory studies the interface between cellular metabolism and signal transduction, with a specific focus on key steps in glucose and lipid metabolism, in order to understand the ways that nutrients can delay aging effects and thus postpone the onset of disease.
Featured Publications
Lee H et al. Proteomic and metabolic characterization of a mammalian cellular transition from quiescence to proliferation. Cell Rep.
Waldhart AN et al. Phosphorylation of TXNIP by AKT mediates acute influx of glucose in response to insulin. Cell Rep.
Wu N et al. AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. Mol Cell.
Join our team
The Wu Laboratory has an opening for a postdoctoral fellow who has significant experience in cellular signaling and metabolism, and who is familiar with techniques including tissue culture, western blot, qPCR, cloning and immunoprecipitation. The lab studies glucose and lipid metabolism in metabolic disease and aging, particularly how diet affects inflammation which plays a role in development of many diseases. For more information or to apply, please visit the posting here.